| Cat. No. |
Product Name |
Information |
| PC-42754 |
DMXAA
STING agonist
|
DMXAA (ASA-404, Vadimezan) is a vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM, also is a partial STING agonist, competes for human STING activation and STING dependent innate immune pathways. |
| PC-27260 |
UM-232
STING inhibitor
|
UM-232 is a selecitve, next-generation, covalent STING inhibitor wth EC50 of 2.6 uM in THP1 R232 cells, inhibits STING oligomerization. |
| PC-26989 |
MSA-2 dimer
STING agonist
|
MSA-2 dimer (diMSA-2) is a selective, orally active non-nucleotide STING agonist with KD of 145 uM, binds to STING as a non-covalent dimer and exhibits long-term antitumor and immunogenic activity. |
| PC-26988 |
Caged-diBSP01
STING agonist
|
Caged-diBSP01 is the first photoactivatable STING agonist diBSP01, can binds to and activate STING at 400 nm irradiation led to the liberation of the parent drug diBSP01. |
| PC-26987 |
diBSP01
STING agonist
|
diBSP01 is a potent dimer agonist of STING, exhibits promising binding properties (ITC KD=218 nM, hSTINGH232 protein) and agonistic potency in vitro. |
| PC-26958 |
DDO-88109
STING inhibitor
|
DDO-88109 is a potent small molecule STING inhibitor with SPR Kd of 317 nM for hSTING-CTDWT, shows broad affinity for hSTING isoforms (WT, HAQ, and H232) and selectively suppresses the activation of cGAS-STING signaling pathway. |
| PC-26653 |
SH-273
STING agonist, PI3Kγ inhibitor
|
SH-273 is a dual functional compound that simultaneously activate STING and inhibit PI3Kγ, stimulates STING activity (IC50=29.6 nM) in THP-1 Blue ISG cells (STING reporter) and inhibited PI3Kγ (IC50=20.2 nM). |
| PC-26652 |
STING inhibitor Y-320
STING inhibitor
|
Y-320 is a specific, allosteric small-molecule STING inhibitor, inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20-60 nM, blocks STING Golgi translocation and downstream signaling. |
| PC-26568 |
KSI-028
STING inhibitor
|
KSI-028 is a potent, specific STING inhibitor with IC50 of 0.652 uM in reporter assay in RAW264.7 cells. |
| PC-26425 |
UM-200
STING inhibitor
|
UM-200 is a specific small molecule inhibitor of cGAS-STING pathway with EC50 of 1.1 uM in THP1-Dual cells that overexpress wild-type STING, blocks STING oligomerization, inhibits STING activation and signaling. |
| PC-25518 |
Salvianolic acid A
STING modulator
|
Salvianolic acid A (SAL A, SAA) is a phenolic acid substance extracted from the plant Salvia miltiorrhiza Bunge, possessing antioxidant, neuroprotective effects, and anti-platelet aggregation properties, also effectively inhibits LCMV infection as a cap-dependent endonuclease inhibitor, also directly interacts with STING and regulates the TBK1/IRF3 signaling pathway. |
| PC-24987 |
STING activator diABZI-a1
STING agonist
|
STING activator diABZI-a1 is a potent, small molecule activator of STING, elicits IFNβ in human PBMCs with EC50 of 117 nM. |
