| Cat. No. |
Product Name |
Information |
| PC-38104 |
DUN99845
STING antagonist
|
DUN99845 (SN-001) is a STING inhbitor and inhibits the activation of the STING signal pathway. |
| PC-38087 |
SR-717
STING agonist
|
SR-717 (SR717) is a non-nucleotide, small-molecule STING agonist, demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 uM and 2.2 uM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines. |
| PC-36011 |
STING inhibitor 18
STING inhibitor
|
STING inhibitor 18 is a novel cGAMP competitive ligand (antagonist) of the inactive form of STING with IC50 of 68 nM in the HAQ STING cGAMP displacement assays. |
| PC-35785 |
STING agonist diABZI compound 3
STING agonist
|
STING agonist diABZI compound 3 (diABZI-3) is an amidobenzimidazole (ABZI)-based compound that functions as a potent, specific, non-nucleotide STING agonist, induces dose-dependent activation of STING and secretion of IFN-β with EC50 of 130 nM in human PBMCs. |
| PC-35784 |
STING agonist diABZI-3
STING agonist
|
STING agonist diABZI-3 is an amidobenzimidazole (ABZI)-based compound that functions as a potent, specific, non-nucleotide STING agonist, induces dose-dependent activation of STING and secretion of IFN-β with EC50 of 130 nM in human PBMCs. |
| PC-35783 |
STING agonist diABZI compound 2
STING agonist
|
STING agonist diABZI compound 2 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates). |
| PC-35547 |
STING CDN agonist IFM Therapeutics
STING agonist
|
STING CDN agonist IFM Therapeutics is a synthetic cyclic dinucleotide (CDN) agonist of STING, stimulates potent immunity against cancer.. |
| PC-35434 |
SINCRO
STING agonist
|
SINCRO is a novel anti-cancer compound that can activate the cytosolic DNA-sensing STING signaling pathway leading to the induction of type I interferon (IFN) genes. |
| PC-35312 |
STING inhibitor H-151
STING inhibitor
|
STING inhibitor H-151 (H151) is a highly potent, selective, covalent small-molecule antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo. |
| PC-35311 |
STING inhibitor C-176
STING inhibitor
|
STING inhibitor C-176 (C176) is a covalent, in vivo-active, small-molecule inhibitor of STING, attenuates STING-associated autoinflammatory disease in mice. |
| PC-35310 |
STING inhibitor C-178
STING inhibitor
|
STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING. |
| PC-63270 |
ChX710
ISRE inducer, STING agonist
|
ChX710 (ChX0306710) is a small molecule Interferon-Stimulated Response Elements (ISRE) inducer that primes the type I interferon response to cytosolic DNA, which is dependent on the adaptor MAVS and IRF1, but not the IRF3. |
