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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-UM-200
UM-200

Chemical Structure : UM-200

CAS No.:

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UM-200 (UM200)

货号: PC-26425Not For Human Use, Lab Use Only.

UM-200 is a specific small molecule inhibitor of cGAS-STING pathway with EC50 of 1.1 uM in THP1-Dual cells that overexpress wild-type STING, blocks STING oligomerization, inhibits STING activation and signaling.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UM-200 is a specific small molecule inhibitor of cGAS-STING pathway with EC50 of 1.1 uM in THP1-Dual cells that overexpress wild-type STING, blocks STING oligomerization, inhibits STING activation and signaling.
UM-200 inhibits STING activation via the covalent modification of C292 or C309, but not C91.
UM-200 (0.2-1 uM) inhibited the diABZI induced transcription of the IFNβ and IL6 genes in mouse macrophages. (2.5 uM) blocks the STING-dependent induction of IFNβ secretion in primary human CD14+ monocytes.
UM-200 also inhibited the diABZI induced phosphorylation of TBK1 and IRF3 in iBMBMs.

物理化学性质&存储条件

分子量 443.53
分子式 C24H21N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(1-(1-methyl-1H-benzo[d]imidazol-2-yl)-3-propiolamidopropyl)-2-phenylthiazole-5-carboxamide

参考文献

1. Barasa L, et al. J Med Chem. 2026 Mar 23. doi: 10.1021/acs.jmedchem.6c00237.

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