| Cat. No. |
Product Name |
Information |
| PC-22374 |
DDD00057570
Aminopeptidase M17 inhibitor
|
DDD00057570 is a selective inhibitor of Leishmania major M17 leucyl-aminopeptidase (LAP) with IC50 of 3.3 uM, exhibits in vitro antileishmanial activity. |
| PC-22373 |
MMV1557817
Aminopeptidase M1/M17 inhibitor
|
MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 (Ki=308/19 nM) and M17 (Ki=112/208 nM), demonstrates potent activity against asexual and sexual stage parasites. |
| PC-22334 |
NPD8790
Complex I inhibitor
|
NPD8790 is a species-selective inhibitor of mitochondrial respiratory complex I with IC50 of 1.6, 2.1 and 1.1 uM for C. briggsae, P. pacificus and P. hermaphrodita complex I, respectively, does not inhibit human mitochondria with IC50 of >75 uM. |
| PC-21997 |
mCMY416
PheRS inhibitor
|
mCMY416 is a potent and selective inhibitor of Toxoplasma gondii phenylalanine tRNA synthetase (PheRS), potently inhibits T. gondii growth with EC90 of 0.38 uM. |
| PC-21960 |
NF2839
SmHDAC8 inhibitor
|
NF2839 is a quinolone-based HDAC inhibitor with IC50 of 0.1 uM for S. mansoni HDAC8 (SmHDAC8), inhibits S. mansoni larval stage with LD50 of 10.6 uM. |
| PC-21811 |
AWZ1066S
Wolbachia inhibitor
|
AWZ1066S is a potent, highly specific anti-Wolbachia inhibitor with EC50 of 2.5 nM against Wolbachia in cell-based assays, and IC50 of 121 nM in microfilaria assays. |
| PC-21802 |
MMV019266
Antibabesial inhibitor
|
MMV019266 is a potent antibabesial inhibitor with IC50 of 0.278 uM and 0.909 uM for Babesia spp. (B. bovis and B. divergens), respectively. |
| PC-21591 |
T. cruzi bc1 inhibitor compound 4
T. cruzi bc1 inhibitor
|
T. cruzi bc1 inhibitor compound 4 is a highly selective and efficacious T. cruzi cytochrome b inhibitor with IC50 of 6 nM, exhibits potent activity against intracellular amastigotes with EC50 of 0.08 uM. |
| PC-21577 |
OJT008
Mtb MetAP1 inhibitor
|
OJT008 is a small molecule Mtb. MetAP inhibitor against M. tuberculosis, has MIC50 of 0.063 µg/mL against both active and MDR Mtb. |
| PC-21539 |
MMV693183
Antiparasite
|
MMV693183 is a first-in-class acetyl-CoA synthetase (AcAS) inhibitor and potent antimalarial drug candidate (Asexual blood stage IC50=2.1-2.8 nM). |
| PC-21445 |
CZC-54252
Anti-parasite
|
CZC-54252 is a small molecule inhibitor of five P. falciparum kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB with IC50 of 3.4, 1.8, 1.0, 1.2 and 0.07 uM, respectively. |
| PC-21377 |
Antitrypanosomal agent 10
Antitrypanosomal
|
Antitrypanosomal agent 10 is a potent, orally active antitrypanosomal compound, selectively inhibits the growth of parasites T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50 of 0.54, 0.13 and 1.14 uM, resepctively. |
