| Cat. No. |
Product Name |
Information |
| PC-35984 |
NEU-1953
Anti-parasite
|
NEU-1953 (NEU1953) is a potent inhibitor of P. falciparum with EC50 of 0.43 uM (T. brucei), demonstrates improved ADME profile over the NEU-961.. |
| PC-35930 |
HS220
PfPK9 inhibitor
|
HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum. |
| PC-35894 |
GSK3186899
Parasite CRK12 inhibitor
|
GSK3186899 (GSK-3186899, DDD853651) is a novel specific inhibitor of parasite cdc-2-related kinase 12 (CRK12), shows activity against L. donovani in intra-macrophage assay with EC50 value of 1.4 uM, and shows good selectivity against mammalian THP-1 host cells (EC50> 50 uM). |
| PC-35257 |
Antimalarial compound 49c
Antimalarial
|
Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM. |
| PC-35114 |
N205
Antimalarial
|
N205 is a novel anti-malaria compound with in vitro IC50 of 1.3 nM against Plasmodium falciparum (3D7). |
| PC-63381 |
Tafenoquine
Antimalarial
|
Tafenoquine (SB-252263, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum. |
| PC-63378 |
Cipargamin
Antimalarial
|
Cipargamin (KAE609, NITD609) is a fast-acting, potent antimalarial agent that inhibits blood-stage activity in vitro against a panel of culture-adapted P. falciparum strains with IC50 of 0.5-1.4 nM. |
| PC-63332 |
Bm-MPK1-IN-15b
|
Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM. |
| PC-63237 |
DNDI-8219
|
DNDI-8219 is a novel potent, orally active antileishmanial agent with IC50 of 0.19 uM against Leishmania donovani (L. don). |
| PC-62987 |
Artefenomel
Antimalarial
|
Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM). |
| PC-62611 |
JPC-3210
Antimalarial
|
JPC-3210 is a potent antimalarial agent with IC50 of 2.5-19 nM, remains activity against multidrug-resistant Plasmodium falciparum lines with little cytotoxicity in mammalian cell lines. |
| PC-62608 |
FR900098 sodium
Antimalarial
|
FR900098 sodium is a derivative of fosmidomycin that inhibits DOXP reductoisomerase, demonstrates antimalarial activity with IC50 of 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively. |
