WJM664

Chemical Structure : WJM664

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货号: PC-24371Not For Human Use, Lab Use Only.

WJM664 is a small molecule inhibitor of P. falciparum malaria P-type ATPase 4 (PfATP4), inhibits P. falciparum 3D7 parasite growth with EC50 of 13 nM.

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生物&药学活性

WJM664 is a small molecule inhibitor of P. falciparum malaria P-type ATPase 4 (PfATP4), inhibits P. falciparum 3D7 parasite growth with EC50 of 13 nM.
WJM664 is potent against both male and female gametes with EC50 of 0.18 and 0.25 uM in dual gamete formation assays.
WJM664 inhibited gamete development and blocked parasite transmission to mosquitoes but exhibited low efficacy in aPlasmodium berghei mouse model, which was attributed to ATP4 species differentiation and its moderate systemic exposure.

物理化学性质&存储条件

分子量	472.90
分子式	C23H22ClFN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-Chloro-5-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1H-indol-1-yl)-N-(3,4,5-trimethoxyphenyl)acetamide

参考文献

1. Awalt JK, et al. J Med Chem. 2025 Apr 14. doi: 10.1021/acs.jmedchem.5c00614.

WJM664

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WJM664

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