| Cat. No. |
Product Name |
Information |
| PC-23158 |
AN-329
Hsp110 inhibitor
|
AN-329/43448068 (AN-329) is a small molecule inhibitor of Hsp110-STAT3 association, effectively inhibits HPAECs proliferation with IC50 of 22.67 uM, binds to bind to Hsp110 with KD of 12.6 uM. |
| PC-22212 |
HVH-2930
HSP90 inhibitor
|
HVH-2930 is a specfiic small molecule C-terminal HSP90 inhibitor with SPR KD of 97.2 uM (HSP90α), reduces cell viability and induces apoptosis in HER2-positive breast cancer cells, targets the C-terminal HSP90 without inducing heat shock response (HSR). |
| PC-21234 |
XL888
HSP90 inhibitor
|
XL888 is a potent small molecule inhibitor of HSP90 with IC50 of 24 nM, inhibits cell proliferation of multiple cancer cell types. |
| PC-21226 |
EC144
HSP90 inhibitor
|
EC144 (EC-144) is a potent, second generation inhibitor of heat shock protein 90 (Hsp90) with IC50 of 1.1 nM in Hsp90α binding assay, degrades Her-2 in MCF-7 cells with EC50 of 14 nM. |
| PC-21200 |
NVP-HSP990
HSP90 inhibitor
|
NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively. |
| PC-20807 |
HLQ2H
Hsp110-STAT3 inhibitor, Msi3 inhibitor
|
HLQ2H (Msi3 inhibitor 2H) is a first-in-class, specific inhibitor of fungal Hsp110 molecular chaperone Msi3, inhibits the holdase activity of Msi3 (IC50=5.02 uM) as well as the growth and viability of C. albicans. |
| PC-20710 |
STA-9090
HSP90 inhibitor
|
Ganetespib (STA 9090) is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM). |
| PC-20709 |
STA-1474
HSP90 inhibitor
|
STA-1474 is a water soluble prodrug of Ganetespib (STA 9090), which is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM). |
| PC-49868 |
Debio 0932
HSP90 inhibitor
|
Debio 0932 (CUDC-305, RGRN-305) is a highly potent, oral and BBB-penetrant HSP90 inhibitor, shows high affinity for HSP90alpha/beta and HSP90 complex derived from cancer cells with IC50 of 100 nM and 48.8 nM, respectively. |
| PC-49842 |
PST inhibitor peptide-8
Pancreastatin inhibitor
|
PST inhibitor peptide-8 (PSTi8) is a potent pancreastatin (PST) inhibitor, competes with PST on GRP78 receptor binding and rescues PST-induced insulin resistance (IR) both in vitro and in vivo. |
| PC-49775 |
KUNG65
Grp94 inhibitor
|
KUNG65 is a potent, selective glucose regulated protein 94 (Grp94) inhibitor with Kd value of 540 nM in fluorescence polarization assays, 73-fold selectivity over Hsp90α. |
| PC-49670 |
VER-50589
Hsp90 inhibitor
|
VER-50589 (VER50589) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 21 nM and Kd value of 4.5 nM. |
