| Cat. No. |
Product Name |
Information |
| PC-42558 |
Alvespimycin
HSP90 inhibitor
|
Alvespimycin (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM. |
| PC-42458 |
17-AAG hydrochloride
HSP90 inhibitor
|
17-AAG hydrochloride (Tanespimycin hydrochloride) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays. |
| PC-42457 |
17-AAG
HSP90 inhibitor
|
17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays. |
| PC-42747 |
VER-155008
Hsp70 inhibitor
|
VER-155008 (VER155008) is a potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78. |
| PC-42416 |
TRC051384
HSP70 inducer, HSF1 activator
|
TRC051384 is a potent heat shock protein 70 (HSP70) inducer, involves HSF1 activation. |
| PC-42748 |
NVP-BEP800
Hsp90 inhibitor
|
NVP-BEP800 (VER-82576) is a potent and selective HSP90 inhibitor with IC50 of 58 nM for HSP90β. |
| PC-42461 |
NVP-AUY922
HSP90 inhibitor
|
NVP-AUY922 (Luminespib, AUY922) is a potent and selective HSP90 inhibitor with IC50 of 21 and 7.8 nM for HSP90β and HSP90α, respectively. |
| PC-45521 |
PU-WS13
Grp94 inhibitor
|
PU-WS13 is a potent and selective Grp94 inhibitor with IC50 of 0.22 uM. |
| PC-45512 |
ML346
HSP70 activator
|
ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression. |
| PC-27670 |
Puerarin
GRP78 agonist
|
Puerarin is an isoflavone isolated from kudzu with multifaceted anticancer activity, also has lipid-lowering and reproductive-protective properties, binds and enhances the chaperone activity of GRP78, stabilizes steroidogenic acute regulatory protein (StAR) and upregulates its expression. |
| PC-27258 |
Evodiamine
HSP90 inhibitor, DKK2 inhibitor
|
Evodiamine ((+)-Evodiamine) is a natural alkaloid derived from Evodiae Fructus with promising antitumor activity, is a heat shock protein 90 (Hsp90) inhibitor, also exhibits a potential binding interaction with Dickkopf 2 (DKK2), suppresses the Wnt/β-catenin signaling pathway in osteosarcoma cells, suppresses cancer cell proliferation through the induction of apoptosis and cell cycle arrest. |
| PC-26801 |
HSP110 inhibitor C7
HSP110 inhibitor
|
HSP110 inhibitor C7 is a potent, second generation heat shock protein 110 (HSP110) inhibitor, inhibits STAT3 activation, inhibits colorectal cancer cells proliferation. |
