MPT1B098

Chemical Structure : MPT1B098

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货号: PC-28156Not For Human Use, Lab Use Only.

MPT1B098 is a potent, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitor with IC50 of 1.77 uM and 19 nM respectively, inhibits growth of both TMZ-sensitive and -resistant GBM cells.

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100 mg		Get quote

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生物&药学活性

MPT1B098 is a potent, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitor with IC50 of 1.77 uM and 19 nM respectively, inhibits growth of both TMZ-sensitive and -resistant GBM cells.
MPT1B098 increases HSP70 expression indicating reduced function of HSP90, reduced HER2 and phospho-Akt expression similar to MAO A or HSP90 inhibitor itself.
MPT1B098 decreases IFN-γ induced PD-L1 expression in GL26 cells.
MPT1B098 reduces tumor growth in GL26 mouse model.
MPT1B098 also inhibits the growth of colon cancer, leukemia, non-small cell lung and other cancers.

物理化学性质&存储条件

分子量	444.96
分子式	C24H29ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chloro-4-(3-(methyl(prop-2-yn-1-yl)amino)propoxy)phenyl)-2,4-dihydroxy-5-isopropyl-N-methylbenzamide

参考文献

1. Tseng HJ, et al. Front Pharmacol. 2026 Aug 24;17:1866411.

2. Tseng H. J., et al. Eur. J. Med. Chem. 256, 115459.

MPT1B098

生物&药学活性

物理化学性质&存储条件

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MPT1B098

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物理化学性质&存储条件

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