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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KUNA-115
KUNA-115

Chemical Structure : KUNA-115

CAS No.: 2765823-77-4

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KUNA-115 (KUNA115)

货号: PC-26413Not For Human Use, Lab Use Only.

KUNA-115 is a potent, selective Hsp90α inhibitor with IC50 of 0.84 uM in fluorescence polarization (FP) assays, >63-fold selective over Hsp90β.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KUNA-115 is a potent, selective Hsp90α inhibitor with IC50 of 0.84 uM in fluorescence polarization (FP) assays, >63-fold selective over Hsp90β.
KUNA-115 selectively inhibits cell growth of non-small cell lung cancer cell line, NCI-H522, melanoma cell line UACC-62, ovarian cancer cell line SK-OV-3, and renal cell carcinoma cell line UO-31.
KUNA-115 shows completely restrict cell permeability, retains Hsp90 isoform selectivity, does not induce intracellular Hsp90 client degradation, stimulation of the HSR or disruption of hERG channel maturation.

物理化学性质&存储条件

分子量 375.49
分子式 C23H21NO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-((3,4-dimethylphenyl)thio)-4-hydroxyphenyl)(isoindolin-2-yl)methanone

参考文献

1. Sanket J Mishra, et al. Angew Chem Int Ed Engl. 2021 May 3;60(19):10547-10551.

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