| Cat. No. |
Product Name |
Information |
| PC-45068 |
Eleclazine hydrochloride
I(Na,late) inhibitor
|
Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
| PC-45252 |
Flecainide acetate
Nav1.5 inhibitor, RyR2 inhibitor
|
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-27929 |
Carbamazepine
Sodium channel blocker, HDAC inhibitor
|
Carbamazepine (NSC 169864) is an orally active pressure-sensitive sodium ion channel blocker, blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50=2 uM), is an anticonvulsant. |
| PC-27928 |
Oxcarbazepine
Sodium channel blocker
|
Oxcarbazepine (GP47680) is a sodium channel blocker, significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines, shows anti-cancer and anticonvulsant effects. |
| PC-27490 |
Onzotrigine
Nav1.8 inhibitor
|
Onzotrigine (LTG-001) is a potent, selective voltage-gated sodium channel Nav1.8 inhibitor. |
| PC-27413 |
Buratrigine
Nav1.8 inhibitor
|
Buratrigine is a potent, selective Nav1.8 inhibitor. |
| PC-27210 |
Nav1.5 inhibitor KH2
Nav1.5 inhibitor
|
Nav1.5 inhibitor KH2 is an effective Nav1.5 inhibitor with IC50 of 1.38 uM, reduces cardiac conduction. |
| PC-27185 |
Lamotrigine
CAS 84057-84-1
|
Lamotrigine (BW430C) is a potent and orally active anticonvulsant and antiepileptic agent, selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. |
| PC-27184 |
Tetracaine
RyR inhibitor, Nav1.7 inhibitor
|
Tetracaine (Amethocaine) is a sodium channel inhibitor and ryanodine receptor (RyR) inhibitor, blocks sodium conduction across nerve cell membranes, preventing rapid sodium ion influx and depolarization. |
| PC-26991 |
Rufinamide
Nav1.1 blocker
|
Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, limits the firing of sodium-dependent action potentials in neurons, functions as a Nav1.1 channel blocker. |
| PC-26525 |
S3226
NHE3 inhibitor
|
S3226 is a potent, selective Na+/H+ exchanger subtype 3 (NHE3, SLC9A3) inhibitor with IC50 of 0.02 uM (hNHE3), shows >100-fold selectivity over hNHE1 and rbNHE2. |
| PC-26470 |
AM-2099
NaV1.7 inhibitor
|
AM-2099 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.7 with IC50 of 0.16 uM (hNaV1.7), with no actiivity against hNaV1.5. |
