| Cat. No. |
Product Name |
Information |
| PC-27682 |
Obacunone
PPARα activator, Nrf2 activator
|
Obacunone is a naturally occurring limonoid triterpenoid with potent anti-inflammatory and antioxidant effects, activates PPARα, activates the Nrf2 signaling pathway, blocks the interaction between Nrf2 and KEAP1, and suppresses Nrf2 ubiquitination and degradation. |
| PC-27621 |
Sinomenine
Keap1-Nrf2 inhibitor
|
Sinomenine is a natural alkaloid with potential anti-fibrotic activity, inhibits the binding of Keap1 to Nrf2, promotes the nuclear accumulation of Nrf2, induces upregulated expressions of Nrf2-dependent antioxidative genes. |
| PC-27017 |
Keap1-p-p62-IN-2
Nrf2 inhibitor, Keap1-p-p62 inhibitor
|
Keap1-p-p62-IN-2 is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.096 uM, >6-fold selectivity over inhibition of Keap1-Nrf2 interaction. |
| PC-27016 |
Keap1-p-p62 inhibitor 13
Nrf2 inhibitor, Keap1-p-p62 inhibitor
|
Keap1-p-p62 inhibitor 13 (Keap1-p-p62-IN-1) is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.11 uM, high selectivity over inhibition of Keap1-Nrf2 interaction. |
| PC-25792 |
Astilbin
Nrf2 activator
|
Astilbin is a flavonoid compound and enhances NRF2 activation, also suppresses TNF-α expression and NF-κB activation, shows antioxidative, anti-inflammatory, and antitumor properties. |
| PC-25722 |
Bardoxolone
Nrf2 agonist
|
Bardoxolone (RTA401, CDDO) is a covalent, orally active activator of NRF2, also inhibits SARS-CoV-2 3CL protease (EC50=0.43 uM), also inhibits necroptosis in HT-29 cells by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. |
| PC-25376 |
Keap1-Nrf2 inhibitor 28
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 28 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 8.8 nM, induces expression of NQO1 mRNA with EC50 of 60.1 nM in BEAS-2B cells with qPCR-based assays. |
| PC-25375 |
Keap1-Nrf2 inhibitor 24
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 24 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 10 nM, induces expression of NQO1 mRNA with EC50 of 110 nM in BEAS-2B cells with qPCR-based assays. |
| PC-25215 |
CDDO-TFEA
Nrf2 activator
|
CDDO-TFEA (RTA 404, TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier, an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. |
| PC-25206 |
Luteolin
Nrf2 inhibitor, PRDX2 inhibitor
|
Luteolin (Luteoline) is a flavanoid, potent Nrf2 inhibitor, also binds to PRDX2, inhibiting the JAK2/STAT3 pathway, has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis. |
| PC-25023 |
Rosolutamide
Nrf1/ Nrf2 activator
|
Rosolutamide (ASC-JM17) is a curcumin analog, an orally active, potent Nrf1 and Nrf2 activator, activates Nrf1, Nrf2, and heat shock factor 1 (Hsf1), which in turn activates the expression of proteasome subunits, antioxidant enzymes, and molecular chaperones. |
| PC-24918 |
UD-051
Nrf2 activator
|
UD-051 is a potent Nrf2 activator and inhibitor of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 interaction, activates NQO1 in Hepa1c1c7 cells with EC50 of 0.36 nM. |
