| Cat. No. |
Product Name |
Information |
| PC-25376 |
Keap1-Nrf2 inhibitor 28
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 28 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 8.8 nM, induces expression of NQO1 mRNA with EC50 of 60.1 nM in BEAS-2B cells with qPCR-based assays. |
| PC-25375 |
Keap1-Nrf2 inhibitor 24
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 24 is a high potent small molecule inhibitor of Keap1-Nrf2 with Ki of 10 nM, induces expression of NQO1 mRNA with EC50 of 110 nM in BEAS-2B cells with qPCR-based assays. |
| PC-25215 |
CDDO-TFEA
Nrf2 activator
|
CDDO-TFEA (RTA 404, TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier, an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. |
| PC-25206 |
Luteolin
Nrf2 inhibitor, PRDX2 inhibitor
|
Luteolin (Luteoline) is a flavanoid, potent Nrf2 inhibitor, also binds to PRDX2, inhibiting the JAK2/STAT3 pathway, has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis. |
| PC-25023 |
Rosolutamide
Nrf1/ Nrf2 activator
|
Rosolutamide (ASC-JM17) is a curcumin analog, an orally active, potent Nrf1 and Nrf2 activator, activates Nrf1, Nrf2, and heat shock factor 1 (Hsf1), which in turn activates the expression of proteasome subunits, antioxidant enzymes, and molecular chaperones. |
| PC-24918 |
UD-051
Nrf2 activator
|
UD-051 is a potent Nrf2 activator and inhibitor of Kelch-like ECH-associated protein 1 (Keap1) and Nrf2 interaction, activates NQO1 in Hepa1c1c7 cells with EC50 of 0.36 nM. |
| PC-24870 |
Nrf2 agonist C5
Nrf2 agonist
|
Nrf2 agonist C5 is a novel chalcone-derived covalent Keap1 binder and Nrf2 agonist, strongly blocks Keap1-Nrf2 interaction and enhances Nrf2 stability. |
| PC-24785 |
CB5712809
Keap1 inhibitor
|
CB5712809 is a high affinity Keap1 inhibitor, inhibits Keap1:Nrf2 activity with IC50 of 36.7 nM. |
| PC-24727 |
CBR-470-1
PGK1 inhibitor, NRF2 activator
|
CBR-470-1 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo. |
| PC-24726 |
CBR-470-2
PGK1 inhibitor, NRF2 activator
|
CBR-470-2 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo. |
| PC-24522 |
WCDD115
NRF2 inhibitor, DHFR inhibitor
|
WCDD115 is a potent indirect inhibitor of NRF2 expression with IC50 of 57 nM (inhibition of eYFP quantitation in H1299 NQO1-eYFP cells), inhibits hDHFR with IC50 of 144 nM, suppresses endogenous metrics of NRF2 signal transduction irrespective of KEAP1 expression. |
| PC-24350 |
Eriodictyol
552-58-9
|
Eriodictyol (Huazhongilexone) is a small molecule activator of BMPR2, induces Nrf2 signaling pathway, also is a potent influenza RNA-dependent RNA polymerase inhibitor with IC50 of 18 nM. |
