Obacunone

Chemical Structure : Obacunone

CAS No.: 751-03-1

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货号: PC-27682Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥880	In stock
50 mg	￥1280	In stock
100 mg		Get quote

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生物&药学活性

Obacunone is a naturally occurring limonoid triterpenoid with potent anti-inflammatory and antioxidant effects, activates PPARα, activates the Nrf2 signaling pathway, blocks the interaction between Nrf2 and KEAP1, and suppresses Nrf2 ubiquitination and degradation.
Obacunone regulates bile acid metabolism, fatty acid oxidation, inflammatory responses.
Obacunone inhibits human colon cancer (SW480) cells by the induction of apoptosis.
Obacunone inhibits ferroptosis, exhibits significant anti‑diabetic nephropathy (DN).

物理化学性质&存储条件

分子量	454.52
分子式	C26H30O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3aS,4aR,4bR,6aR,11aR,11bR,13aS)-1-(furan-3-yl)-4b,7,7,11a,13a-pentamethyl-1,6a,7,11a,11b,12,13,13a-octahydrooxepino[4',3':3,4]benzo[1,2-f]oxireno[2,3-d]isochromene-3,5,9(3aH,4bH,6H)-trione

参考文献

1. Yi Ou, et al. Mol Med Rep. 2025 May;31(5):135.

2. Kim J, et al. Biochimie. 2014 Oct;105:36-44.

3. Chidambara Murthy KN, et al. Food Chem Toxicol. 2011 Jul;49(7):1616-25.

4. Xiangqi Meng, et al. Phytomedicine. 2026 Jul 25:160:158648.

Obacunone

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Obacunone

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