| Cat. No. |
Product Name |
Information |
| PC-72862 |
PRL-295
Keap1-Nrf2 inhibitor
|
PRL-295 is a small molecule Keap1-Nrf2 protein-protein interaction inhibitor. |
| PC-38190 |
MSU38225
Nrf2 inhibitor
|
MSU38225 (MSU-38225) is a novel small molecule that inhibit the Nrf2 pathway, potentially inhibiting Nrf2 transcriptional activity and cancer cell growth. |
| PC-35259 |
Brusatol
Nrf2 inhibitor
|
Brusatol (NSC 172924, (+)-Brusatol) is a quassinoid extracted from Brucea Esters, can inhibit HIF-1 signaling pathway, also is a potent Nrf2 inhibitor. |
| PC-43494 |
Bardoxolone methyl
Nrf2 activator
|
Bardoxolone methyl (CDDO-Me, RTA402) is a potent activator of Nrf2, inhibits proliferation, induces differentiation and apoptosis in AML cells. |
| PC-63001 |
Sulforaphane
Nrf2 activator
|
Sulforaphane (SFN) is an antioxidant agent that exerts protective effects against cell damage by activating Nrf2. |
| PC-62796 |
K67
p62-Keap1 inhibitor
|
K67 is a specific inhibitor of the interaction between S349-phosphorylated p62 and Keap1, exhibts no inhibitory effect on the interaction of full-length Keap1 with Nrf2-ETGE or full-length Nrf2. |
| PC-62795 |
Nrf2 activator 16
Nrf2 activator
|
Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively. |
| PC-62575 |
QD325
Nrf2 activator
|
QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM). |
| PC-62430 |
AI-2
Nrf2 activator
|
Nrf2 activator AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1. |
| PC-62429 |
AI-1
Nrf2 activator
|
Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM. |
| PC-62392 |
AEM1
Nrf2 inhibitor
|
NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC). |
| PC-70279 |
MIND4-17
Nrf2 activator
|
MIND4-17 is an inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM. |
