| Cat. No. |
Product Name |
Information |
| PC-42917 |
CDDO-EA
Nrf2 activator
|
CDDO-EA (DDO ethyl amide, RTA405) is a potent Nrf2 activator that upregulates Nrf2 expression and resulted in translocation of Nrf2 into the nucleus. |
| PC-42916 |
RTA-408
Nrf2 activator
|
RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-24785 |
CB5712809
Keap1 inhibitor
|
CB5712809 is a high affinity Keap1 inhibitor, inhibits Keap1:Nrf2 activity with IC50 of 36.7 nM. |
| PC-24727 |
CBR-470-1
PGK1 inhibitor, NRF2 activator
|
CBR-470-1 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo. |
| PC-24726 |
CBR-470-2
PGK1 inhibitor, NRF2 activator
|
CBR-470-2 is a small molecule inhibitor of glycolytic enzyme phosphoglycerate kinase 1 (PGK1), activates NRF2 signaling in vitro and in vivo. |
| PC-24522 |
WCDD115
NRF2 inhibitor, DHFR inhibitor
|
WCDD115 is a potent indirect inhibitor of NRF2 expression with IC50 of 57 nM (inhibition of eYFP quantitation in H1299 NQO1-eYFP cells), inhibits hDHFR with IC50 of 144 nM, suppresses endogenous metrics of NRF2 signal transduction irrespective of KEAP1 expression. |
| PC-24350 |
Eriodictyol
552-58-9
|
Eriodictyol (Huazhongilexone) is a small molecule activator of BMPR2, induces Nrf2 signaling pathway, also is a potent influenza RNA-dependent RNA polymerase inhibitor with IC50 of 18 nM. |
| PC-23581 |
Licochalcone E
Nrf2 activator
|
Licochalcone E (LicoE) is a glycyrrhiza-inflata-derived chalcone, exhibits potent anti-inflammatory properties inhibits Aβ1-42 aggregation and activates Nrf2, also inhibits pancreatic lipase (PL) with IC50 of 5.8 uM. |
