| Cat. No. |
Product Name |
Information |
| PC-45694 |
NK-252
Nrf2 activator
|
NK-252 (NK252) is a small molecule Nrf2 activator, exhibits a greater Nrf2-activating potential than oltipraz (OPZ). |
| PC-45182 |
Dimethyl fumarate
Nrf2 activator
|
Dimethyl fumarate (DMF, BG-12) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, activates the Nrf2 pathway. |
| PC-43044 |
14-3-3 inhibitor WS3
14-3-3 inhibitor, NRF2 inhibitor
|
14-3-3 inhibitor WS3 is a potent, allosteric inhibitor of 14-3-3 proteins, potently inhibits the NRF2-ARE signal with IC50 of 135 nM in A549 cells, selectively inhibits NRF2 activity in tumor cells. |
| PC-42917 |
CDDO-EA
Nrf2 activator
|
CDDO-EA (DDO ethyl amide, RTA405) is a potent Nrf2 activator that upregulates Nrf2 expression and resulted in translocation of Nrf2 into the nucleus. |
| PC-42916 |
RTA-408
Nrf2 activator
|
RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-44663 |
CDDO-Im
PPAR agonist, Nrf2 activator
|
CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42172 |
TBHQ
Nrf2 activator
|
TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
| PC-42187 |
ML385
NRF2 inhibitor
|
ML385 (ML-385) is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-25722 |
Bardoxolone
Nrf2 agonist
|
Bardoxolone (RTA401, CDDO) is a covalent, orally active activator of NRF2, also inhibits SARS-CoV-2 3CL protease (EC50=0.43 uM), also inhibits necroptosis in HT-29 cells by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. |
| PC-25721 |
CH7450924 hydrate
KEAP1-NRF2 inhibitor, NRF2 activator
|
CH7450924 hydrate is a highly potent and selective NRF2 activator, inhibits KEAP1-NRF2 interaction inhibitor, binds non-covalently to the NRF2 binding site of KEAP1. |
| PC-25720 |
CH7450924
KEAP1-NRF2 inhibitor, NRF2 activator
|
CH7450924 is a highly potent and selective NRF2 activator, inhibits KEAP1-NRF2 interaction inhibitor, binds non-covalently to the NRF2 binding site of KEAP1. |
