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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-Keap1-p-p62-IN-2
Keap1-p-p62-IN-2

Chemical Structure : Keap1-p-p62-IN-2

CAS No.: 2616410-78-5

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Keap1-p-p62-IN-2

货号: PC-27017Not For Human Use, Lab Use Only.

Keap1-p-p62-IN-2 is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.096 uM, >6-fold selectivity over inhibition of Keap1-Nrf2 interaction.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Keap1-p-p62-IN-2 is a selective and effective Nrf2 inhibitor that inhibits Kelch-like ECH-associated protein 1-phosphorylated p62 (Keap1-p-p62) interaction with IC50 of 0.096 uM, >6-fold selectivity over inhibition of Keap1-Nrf2 interaction.

物理化学性质&存储条件

分子量 589.70
分子式 C33H35NO7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(tert-butyl)phenyl)-2-((4-((N-(carboxymethyl)-2,4,6-trimethylphenyl)sulfonamido)naphthalen-1-yl)oxy)acetic acid

参考文献

1. Patent WO2017124835 A1.

2. Ziquan Zhao, et al. J Med Chem. 2026 Jun 11;69(11):13141-13164.

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