| Cat. No. |
Product Name |
Information |
| PC-25036 |
Comtifator
eIF2B activator
|
Comtifator is a potent, selective eukaryotic translation initiation factor 2B (eIF2B) activator. |
| PC-25000 |
GCN2-IN-1
GCN2 inhibitor
|
GCN2-IN-1 (Compound A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50 of <0.3 uM in enzyme assays and IC50 of 0.3-3 μM in cellular assays. |
| PC-24999 |
IBX-204
ISR modulator, GCN2 inhibitor
|
IBX-204 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors. |
| PC-24690 |
1Ai-8214
RPS10-eIF1A inhibitor
|
1Ai-8214 is a small molecule inhibitor of RPS10-eIF1A interaction, binds both eIF1A and RPS10. |
| PC-24688 |
1Ai-4927
RPS10 inhibitor
|
1Ai-4927 is a specific inhibitor of ribosomal protein Rps10 with IC50 of 6.1 uM, targets the eIF1A-RPS10 complex,1Ai-4927 binds only RPS10, but not affect eIF1A. |
| PC-24545 |
HR-19011
eIF2α phosphorylation inducer
|
HR-19011 is a specific small molecule eIF2α phosphorylation inducer, increases the expression level of eIF2α downstream proteins, ATF and CHOP, shows antiproliferation in K562 cells with IC50 of 4.0 uM. |
| PC-24503 |
i4EG-BiP
eIF4E inhibitor
|
i4EG-BiP is a specific small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), displaces eIF4G peptide from eIF4E with IC50 of 68 uM, inhibits cap-dependent translation by increasing the eIF4E-4E-BP1 interaction, but not interaction of eIF4E with eIF4G. |
| PC-24502 |
eIF4E-eIF4G inhibitor 4
eIF4E inhibitor
|
eIF4E-eIF4G inhibitor 4 is a specific small molecule inhibitor of eukaryotic initiation factor 4E (eIF4E) with Kd of 0.09 uM, disrupts the eIF4E:eIF4G interaction with EC50 of 1.4 uM (SW620 cell). |
| PC-23798 |
Salubrinal
eIF2α dephosphorylation inhibitor
|
Salubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha, eIF2α) dephosphorylation, also is a potential inhibitor of dual-specificity phosphatase 2 (Dusp2). |
| PC-23755 |
Girolline
eIF5A modulator
|
Girolline (Girodazole) is a sequence-selective modulator of translation factor eIF5A, interferes with ribosome-eIF5A interaction and induces ribosome stalling, an anti-tumor agent as well as having activity against malaria. |
