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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-eIF2B inhibitor Compound B
eIF2B inhibitor Compound B

Chemical Structure : eIF2B inhibitor Compound B

CAS No.:

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eIF2B inhibitor Compound B

货号: PC-26715Not For Human Use, Lab Use Only.

eIF2B inhibitor Compound B is a small molecule stabiliser and allosteric inhibitor of inactive state of eIF2B, shows stabilisation effect of the eIF2B:(P)eIF2-NTD interaction, stimulating the Integrated Stress Response (ISR).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

eIF2B inhibitor Compound B is a small molecule stabiliser and allosteric inhibitor of inactive state of eIF2B, shows stabilisation effect of the eIF2B:(P)eIF2-NTD interaction, stimulating the Integrated Stress Response (ISR).

物理化学性质&存储条件

分子量 951.06
分子式 C52H60F6N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-methyl-3-(2-(3-(methyl(6-(3-((N-methylacetamido)methyl)phenyl)-8-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)-3-oxopropoxy)ethoxy)-N-(7-(3-((N-methylacetamido)methyl)phenyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)propanamide

参考文献

1. Shilliday F, et al. Nat Commun. 2026 May 6. doi: 10.1038/s41467-026-72688-y.

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