4E1RCat

Chemical Structure : 4E1RCat

CAS No.: 328998-25-0

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货号: PC-25457Not For Human Use, Lab Use Only.

4E1RCat is a small moleculeeIF4E:eIF4GI inhibitor, selectively inhibits cap-dependent translation initiation with IC50 of 4 uM, inhibits eIF4E:eIF4G and eIF4E:4E-BP1 interaction.

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5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

4E1RCat is a small moleculeeIF4E:eIF4GI inhibitor, selectively inhibits cap-dependent translation initiation with IC50 of 4 uM, inhibits eIF4E:eIF4G and eIF4E:4E-BP1 interaction.
4E1RCat is cap-specific, shows no inhibitory effect on 80S complex formation on the GpppG-HCV IRES.
4E1RCat inhibits protein synthesis in vivo in MDA-MB-231 and HeLa cells, but does not significantly affect RNA or DNA synthesis.
4E1RCat (25-50 uM) decreases polysomes, increases the fraction of 80S ribosomal subunits, and decreases levels of Mcl-1 and c-Myc proteins, two eIF4E-dependent mRNAs, in Jurkat cells.
4E1RCat alters chemosensitivity of Pten+/-Eμ-Myc tumors in vivo.

物理化学性质&存储条件

分子量	478.46
分子式	C28H18N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

参考文献

1. Cencic R, et al. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1046-51.

4E1RCat

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4E1RCat

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