| Cat. No. |
Product Name |
Information |
| PC-20483 |
eIF4E-RBM38 inhibitor 094
eIF4E-RBM38 inhibitor
|
eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners. |
| PC-49309 |
RBF197
eIF4A inhibitor
|
RBF197 (RBF-197) is a novel highly potent and selective eIF4A inhibitor, inhibits human eIF4A helicase activity with IC50 of 55.2 pM. |
| PC-49308 |
eIF4A inhibitor 28
eIF4A inhibitor
|
eIF4A inhibitor 28 (eIF4A-IN-28) is a novel small molecule RNA-competitive, ATP-uncompetitive inhibitor of eIF4A, inhibits eIF4A ATPase and helicase activities with IC50 of 8.6 and 6.6 uM, respectively. |
| PC-72482 |
Rohinitib
eIF4A1 inhibitor
|
Rohinitib is a potent and specific inhibitor of eIF4A1, inhibits growth and survival of AML cells especially cells with FLT3-ITD. |
| PC-72234 |
EGPI-1
eIF4E/eIF4G inhibitor
|
EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction. |
| PC-36005 |
2BAct
eIF2B activator
|
2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays. |
| PC-35162 |
Elatol
eIF4A1 inhibitor
|
Elatol (NSC 341593) is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types. |
| PC-35083 |
Metarrestin
eEF1A2 inhibitor
|
Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2. |
| PC-43430 |
Silvestrol
eIF4A inhibitor
|
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor. |
| PC-63308 |
eFT226
eIF4A inhibitor
|
Zotatifin (eFT226) is a novel, potent and selective eIF4A inhibitor with anti-tumor activity in B-cell malignancies, promotes eIF4A binding to specific mRNA sequences and interferes with the assembly of the eIF4F initiation complex. |
| PC-62424 |
eIF4A3-IN-2
eIF4A3 inhibitor
|
eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases. |
| PC-61019 |
eIF4A3 inhibitor 53a
eIF4A3 inhibitor
|
eIF4A3 inhibitor 53a is a potent, selective and cell-active eukaryotic initiation factor 4A3 (eIF4A3) inhibitor with IC50 of 0.26 uM, SPR Kd of 43 nM. |
