eIF2B inhibitor Compound A-(S)

Chemical Structure : eIF2B inhibitor Compound A-(S)

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货号: PC-26714Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

eIF2B inhibitor Compound A-(S) is a small molecule stabiliser and allosteric inhibitor of inactive state of eIF2B, shows stabilisation effect of the eIF2B:(P)eIF2-NTD interaction with EC50 of 2.2 uM, stimulating the Integrated Stress Response (ISR).
Compound A-(S) binds the ISRIB pocket of eIF2B, favouring the I-state.
Compound A-(S) binds to eIF2B in complex with phosphorylated eIF2.
Compound A-(S) stabilises the eIF2B decamer and favours eIF2B:eIF2(αP) complex formation.

物理化学性质&存储条件

分子量	563.64
分子式	C30H37F4N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((3R,4S)-3-fluoropiperidin-4-yl)methoxy)-N-methyl-N-((S)-7-(3-((N-methylacetamido)methyl)phenyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)acetamide

参考文献

1. Shilliday F, et al. Nat Commun. 2026 May 6. doi: 10.1038/s41467-026-72688-y.