| Cat. No. |
Product Name |
Information |
| PC-24850 |
BOB-42
RNA Pol I inhibitor
|
BOB-42 is a small molecule inhibitor of RNA polymerase I (Pol I) with IC50 of 0.04 uM and 0.04 uM for degradation of RPA194 and translocation of NCL resepctively. |
| PC-24672 |
SCR130
Ligase IV inhibitor, NHEJ inhibitor
|
SCR130 is a small-molecule inhibitor of nonhomologous end-joining (NHEJ), specifically inhibits Ligase IV with minimal or no effect on Ligase III and Ligase I mediated joining. |
| PC-24443 |
RTx-152
DNA Polθ inhibitor
|
RTx-152 (RTx152) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 6.2 nM, exhibits preferential killing of HR-deficient cells. |
| PC-22343 |
DNA ligase inhibitor L67
DNA ligase inhibitor
|
DNA ligase inhibitor L67 is a competitive DNA ligase inhibitor, effectively inhibits DNA ligases I/III with IC50 of 10 uM for both. |
| PC-21698 |
Fraisinib
GARS1 inhibitor
|
Fraisinib is a specific and effective inhibitor of glycyl-tRNA synthetase 1 (GARS1), suppresses the synthesis of Ap4A by GARS1 and displays strong anti-tumoral potential. |
| PC-20939 |
RBI2
Ribosome biogenesis inhibitor
|
RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM. |
| PC-20598 |
DNA polymerase theta inhibitor
POLθ inhibitor
|
DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity. |
