| Cat. No. |
Product Name |
Information |
| PC-25495 |
RP-2119
DNA Polθ inhibitor
|
RP-2119 (RP2119) is a selective, potent, and bioavailable inhibitor of DNA polymerase theta (Polθ) ATPase inhibitor with IC50 of 0.7 nM (hPOLθ ATPase) in ADP-glo assayss. |
| PC-25301 |
NVL inhibitor MM17
NVL inhibitor
|
NVL inhibitor MM17 is a small molecule inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 0.38 uM, inhibits HCT116 growth in a dose-dependent manner with IC50 of 0.54 uM. |
| PC-25300 |
MM927
NVL inhibitor
|
NVL inhibitor MM927 is a bioavailable analog of MM17 and potent inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 51 nM in cells expressing ectopic human NVL, inhibits HCT116 growth in a dose-dependent manner with IC50 of 53 nM. |
| PC-25138 |
YH-0623
POLRMT inhibitor
|
YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B. |
| PC-24850 |
BOB-42
RNA Pol I inhibitor
|
BOB-42 is a small molecule inhibitor of RNA polymerase I (Pol I) with IC50 of 0.04 uM and 0.04 uM for degradation of RPA194 and translocation of NCL resepctively. |
| PC-24672 |
SCR130
Ligase IV inhibitor, NHEJ inhibitor
|
SCR130 is a small-molecule inhibitor of nonhomologous end-joining (NHEJ), specifically inhibits Ligase IV with minimal or no effect on Ligase III and Ligase I mediated joining. |
| PC-24443 |
RTx-152
DNA Polθ inhibitor
|
RTx-152 (RTx152) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 6.2 nM, exhibits preferential killing of HR-deficient cells. |
| PC-22343 |
DNA ligase inhibitor L67
DNA ligase inhibitor
|
DNA ligase inhibitor L67 is a competitive DNA ligase inhibitor, effectively inhibits DNA ligases I/III with IC50 of 10 uM for both. |
| PC-21698 |
Fraisinib
GARS1 inhibitor
|
Fraisinib is a specific and effective inhibitor of glycyl-tRNA synthetase 1 (GARS1), suppresses the synthesis of Ap4A by GARS1 and displays strong anti-tumoral potential. |
| PC-20598 |
DNA polymerase theta inhibitor
POLθ inhibitor
|
DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity. |
