| Cat. No. |
Product Name |
Information |
| PC-42973 |
Cycloheximide
Protein synthesis inhibitor
|
Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. |
| PC-62219 |
CX-3543
RNA Pol I inhibitor
|
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting RNA Pol I transcription and inducing apoptosis in cancer cells. |
| PC-61350 |
Plicamycin
Sp1 inhibitor
|
Plicamycin (Mithramycin A, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA, inhibits specificity protein 1 (Sp1) transcription factor. |
| PC-61229 |
ML-60218
RNA Pol III inhibitor
|
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively. |
| PC-70241 |
Saframycin A
|
Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro. |
| PC-45353 |
Bleomycin sulfate
|
An anticancer agent that acts by induction of DNA strand breaks. |
| PC-45751 |
COH29
Ribonucleotide reductase inhibitor
|
COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM. |
| PC-42295 |
Beaucage reagent
|
A potent DNA cleavage agent. |
| PC-45350 |
Actinomycin D
Transcription inhibitor
|
Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM. |
| PC-25301 |
NVL inhibitor MM17
NVL inhibitor
|
NVL inhibitor MM17 is a small molecule inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 0.38 uM, inhibits HCT116 growth in a dose-dependent manner with IC50 of 0.54 uM. |
| PC-25300 |
MM927
NVL inhibitor
|
NVL inhibitor MM927 is a bioavailable analog of MM17 and potent inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 51 nM in cells expressing ectopic human NVL, inhibits HCT116 growth in a dose-dependent manner with IC50 of 53 nM. |
| PC-25138 |
YH-0623
POLRMT inhibitor
|
YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B. |
