SEC inhibitor KL-2 |CAS:900308-51-2 Probechem Biochemicals

Chemical Structure : SEC inhibitor KL-2

CAS No.: 900308-51-2

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SEC inhibitor KL-2

货号: PC-35725Not For Human Use, Lab Use Only.

SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC.
SEC inhibitor KL-2 disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation.
SEC inhibitor KL-2 attenuates the heat-shock response from Drosophila to human, reduces protein levels of SEC components AFF1 and AFF4, but not CDK9 or CCNT1 in HEK293T cells.
SEC inhibitor KL-2 downregulates MYC and MYC-dependent transcriptional programs in mammalian cells and delays tumor progression in mouse xenograft models of MYC-driven cancer.

物理化学性质&存储条件

分子量	333.743
分子式	C17H13ClFNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-chloro-2-methylphenyl)-4-(4-fluorophenyl)-2,4-dioxobutanamide

参考文献

1. Liang K, et al. Cell. 2018 Oct 18;175(3):766-779.e17.

SEC inhibitor KL-2

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物理化学性质&存储条件

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SEC inhibitor KL-2

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