SCR7 | NHEJ inhibitor, DNA ligase IV inhibitor | Probechem Biochemicals

Chemical Structure : SCR7

CAS No.: 1533426-72-0

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SCR7 (SCR-7)

货号: PC-43167Not For Human Use, Lab Use Only.

SCR7 is a specific inhibitor of nonhomologous end-joining (NHEJ), blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
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生物&药学活性

SCR7 is a specific inhibitor of nonhomologous end-joining (NHEJ), blocks DNA Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I.
SCR7 inhibits NHEJ in a Ligase IV-dependent manner within cells, causes accumulation of double-strand breaks (DSBs), and activates the intrinsic apoptotic pathway; decreases cell proliferation of MCF7, A549, and HeLa with IC50 of 40, 34, and 44 uM, respectively.
SCR7 increases the efficacy of DSB-inducing therapeutic modalities in mouse xenografts.
SCR7 increases the efficiency of precise genome editing with CRISPR-Cas9 in mammalian cell lines and in mice.

物理化学性质&存储条件

分子量	334.395
分子式	C18H14N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(phenylmethylene)amino]-2-thioxo-

参考文献

1. Srivastava M, et al. Cell. 2012 Dec 21;151(7):1474-87.

2. Greco GE, et al. DNA Repair (Amst). 2016 Jul;43:18-23.

3. Maruyama T, et al. Nat Biotechnol. 2015 May;33(5):538-42.

4. Gkotzamanidou M, et al. Blood. 2016 Sep 1;128(9):1214-25.

SCR7 (SCR-7)

生物&药学活性

物理化学性质&存储条件

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SCR7 (SCR-7)

生物&药学活性

物理化学性质&存储条件

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