L82-G17

Chemical Structure : L82-G17

CAS No.: 92285-87-5

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货号: PC-38570Not For Human Use, Lab Use Only.

L82-G17 is a selective, uncompetitive inhibitor of DNA ligase I, inhibits the third step of the ligation reaction, phosphodiester bond formation.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
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生物&药学活性

L82-G17 is a selective, uncompetitive inhibitor of DNA ligase I, inhibits the third step of the ligation reaction, phosphodiester bond formation.
L82-G17 did not inhibit LigIV.
L82-G17 exhibited increased activity against and selectivity for LigI compared with L82.
Cells lacking nuclear LigIIIα, which can substitute for LigI in DNA replication, were also more sensitive to L82-G17 than isogenic parental cells.

物理化学性质&存储条件

分子量	264.67
分子式	C11H9ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Hydroxybenzaldehyde 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone

参考文献

1. Timothy R L Howes, et al. DNA Repair (Amst). 2017 Dec;60:29-39.

L82-G17

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L82-G17

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