PNR-7-02

Chemical Structure : PNR-7-02

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货号: PC-63201Not For Human Use, Lab Use Only.

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols.

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生物&药学活性

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols.
PNR-7-02 binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η.
PNR-7-02 potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.

物理化学性质&存储条件

分子量	445.921
分子式	C24H16ClN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

参考文献

1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.

PNR-7-02

生物&药学活性

物理化学性质&存储条件

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PNR-7-02

生物&药学活性

物理化学性质&存储条件

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