Plicamycin | Sp1 inhibitor | Probechem Biochemicals

Chemical Structure : Plicamycin

CAS No.: 18378-89-7

加入收藏

Plicamycin (Mithramycin A, PA 144, NSC 24559)

货号: PC-61350Not For Human Use, Lab Use Only.

Plicamycin (Mithramycin A, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA, inhibits specificity protein 1 (Sp1) transcription factor.

规格	价格	库存
2 mg	￥1880	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Plicamycin (Mithramycin A, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA, inhibits specificity protein 1 (Sp1) transcription factor.
Plicamycin binds to the minor groove of DNA at GC-rich sites, induces cancer cell apoptosis and metastasis.

物理化学性质&存储条件

分子量	1085
分子式	C52H76O24
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-3-((1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl)-2-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4-(((2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-

参考文献

1. Boro A, et al. Int J Cancer. 2012 Nov 1;131(9):2153-64.

2. Lee TJ, et al. Mol Cancer Ther. 2006 Nov;5(11):2737-46.

3. Majee S, et al. Biochem Pharmacol. 1999 May 1;57(9):981-7.

Plicamycin (Mithramycin A, PA 144, NSC 24559)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Plicamycin (Mithramycin A, PA 144, NSC 24559)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.