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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-BMH-21
BMH-21

Chemical Structure : BMH-21

CAS No.: 896705-16-1

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BMH-21 (BMH21)

货号: PC-43056Not For Human Use, Lab Use Only.

BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription.

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50 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription.
BMH-21 inhibits the expression of 47S rRNA transcript with IC50 of 60 nM, blocks transcription of the rRNA precursor without affecting rRNA maturation, and causes segregation of nucleolar proteins.
BMH-21 causes proteasome-mediated degradation of RPA194 (Pol I catalytic subunit).
BMH-21 activates p53 and inhibits TP53 null and mutant cell lines with GI50 of 110 and 205 nM, respectively.

物理化学性质&存储条件

分子量 360.4091
分子式 C21H20N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-

参考文献

1. Peltonen K, et al. Cancer Cell. 2014 Jan 13;25(1):77-90.

2. Colis L, et al. J Med Chem. 2014 Jun 12;57(11):4950-61.

3. Colis L, et al. Oncotarget. 2014 Jun 30;5(12):4361-9.

4. Peltonen K, et al. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

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