| Cat. No. |
Product Name |
Information |
| PC-42108 |
CA-074 methyl ester
Cathepsin B inhibitor
|
CA-074 methyl ester is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM. |
| PC-42147 |
Odanacatib
Cathepsin K inhibitor
|
Odanacatib (MK-0822) is a potent, selective, reversible and orally active cathepsin K (CTSK) inhibitor with IC50 of 0.2 nM. |
| PC-45577 |
MG-101
Calpain inhibitor
|
MG-101 (ALLN) is a potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM).
|
| PC-25489 |
z-FA-FMK
Cathepsin B inhibitor
|
Z-FA-FMK ((1S)-Z-FA-FMK) is a potent cathepsin B and cathepsin L inhibitor, inhibits caspase activity in vitro and selectively inhibits recombinant effector caspases 2, -3, -6, and -7, but not caspases 8 and 10. |
| PC-23817 |
CatL inhibitor 1
Cathepsin L inhibitor
|
CatL inhibitor 1 is a potent, selective inhibitor of cathepsin L (CatL) with pIC50 of 7.9, >10-fold selective over CatL2 and >100 fold over CatS/K/B. |
| PC-23639 |
IcatC
CatC inhibitor
|
IcatC (IcatCXPZ-01) is a potent, cell-permeable dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C (CatC, DPP1) with IC50 of 15 nM, selective over cathepsine H, K, L, S, NSPs and DPP4. |
| PC-22251 |
JNJ-10311795
Cathepsin G inhibitor
|
JNJ-10311795 is a potent dual inhibitor of neutrophil cathepsin G (Ki=38 nM) and mast cell chymase (Ki=2.3 nM), exhibits noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and LPS-induced airway inflammation. |
| PC-22250 |
Cathepsin G inhibitor KPA
Cathepsin G inhibitor
|
Cathepsin G inhibitor KPA is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (CatG) with IC50 of 53 nM. |
| PC-22164 |
RO5461111
Cathepsin S inhibitor
|
RO5461111 is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 0.4 nM and 0.5 nM for human and mouse CatS respectively. |
