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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cathepsin-JNJ-10311795
JNJ-10311795

Chemical Structure : JNJ-10311795

CAS No.: 518062-14-1

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JNJ-10311795 (JNJ 10311795, RWJ-355871)

货号: PC-22251Not For Human Use, Lab Use Only.

JNJ-10311795 is a potent dual inhibitor of neutrophil cathepsin G (Ki=38 nM) and mast cell chymase (Ki=2.3 nM), exhibits noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and LPS-induced airway inflammation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JNJ-10311795 is a potent dual inhibitor of neutrophil cathepsin G (Ki=38 nM) and mast cell chymase (Ki=2.3 nM), exhibits noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and LPS-induced airway inflammation.

物理化学性质&存储条件

分子量 670.70
分子式 C40H35N2O6P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carbamoyl)naphthalen-2-yl)-1-(naphthalen-1-yl)-2-oxoethyl)phosphonic acid

参考文献

1. Tausch L, et al. J Immunol. 2009 Sep 1;183(5):3433-42.

2. de Garavilla L, et al. J Biol Chem. 2005 May 6;280(18):18001-7.

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