Odanacatib (MK-0822) | Cathepsin K inhibitor | Probechem Biochemicals

Chemical Structure : Odanacatib

CAS No.: 603139-19-1

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Odanacatib (MK-0822, MK0822)

货号: PC-42147Not For Human Use, Lab Use Only.

Odanacatib (MK-0822) is a potent, selective, reversible and orally active cathepsin K (CTSK) inhibitor with IC50 of 0.2 nM.

规格	价格	库存
2 mg	￥580	In stock
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Odanacatib (MK-0822) is a potent, selective, reversible and orally active cathepsin K (CTSK) inhibitor with IC50 of 0.2 nM.
Odanacatib (MK-0822) displays >300-fold selectivity over cathepsin B, L, S, F, and V.
Odanacatib (MK-0822) demonstrates the potentiation for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling.

物理化学性质&存储条件

分子量	525.5588
分子式	C25H27F4N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥25 mg/mL
Chemical Name/SMILES	Pentanamide, N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-, (2S)-

参考文献

1. Gauthier JY, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8.

2. Kumar V, et al. Mol Pharm. 2009 Jul-Aug;6(4):1118-24.

3. Eisman JA, et al. J Bone Miner Res. 2011 Feb;26(2):242-51.

Odanacatib (MK-0822, MK0822)

生物&药学活性

物理化学性质&存储条件

参考文献

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Odanacatib (MK-0822, MK0822)

生物&药学活性

物理化学性质&存储条件

参考文献

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