JNJ 10329670 | Cathepsin S inhibitor | Probechem Biochemicals

Chemical Structure : JNJ 10329670

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JNJ 10329670 (JNJ-10329670, JNJ10329670)

货号: PC-27080Not For Human Use, Lab Use Only.

JNJ 10329670 (JNJ10329670) is a potent and selective, noncovalent human cathepsin S (CatS) inhibitor with Ki of 30 nM, is much less active against the mouse, dog, monkey, and bovine CatS.

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生物&药学活性

JNJ 10329670 (JNJ10329670) is a potent and selective, noncovalent human cathepsin S (CatS) inhibitor with Ki of 30 nM, is much less active against the mouse, dog, monkey, and bovine CatS.
JNJ 10329670 is inactive against other proteases, including the closely related cathepsins L, F, and K.
JNJ 10329670 induces accumulation of the p10 fragment of the invariant chain in human B cell lines and primary human dendritic cells with IC50 of approximately 1 uM.
JNJ 10329670 blocks the proteolysis of the invariant chain in vivo by using immunocompromised mice injected with human peripheral blood mononuclear cells (PBMCs).
JNJ 10329670 blocks the presentation of tetanus toxoid and giant ragweed by human PBMCs.

物理化学性质&存储条件

分子量	651.15
分子式	C30H34ClF3N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-1-methyl-3-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

参考文献

1. Thurmond RL, et al. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76.

2. Gustin DJ, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1687-91.

JNJ 10329670 (JNJ-10329670, JNJ10329670)

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物理化学性质&存储条件

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JNJ 10329670 (JNJ-10329670, JNJ10329670)

生物&药学活性

物理化学性质&存储条件

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