| Cat. No. |
Product Name |
Information |
| PC-24253 |
z-VAD-fmk
Caspase inhibitor
|
z-VAD-fmk (Z-VAD(OH)-FMK) is a well-known small molecule pan-caspase inhibitor. |
| PC-24248 |
z-IETD-FMK
Caspase-8 inhibitor
|
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM. |
| PC-23804 |
FLIPinB
c-FLIPL inhibitor
|
FLIPinB is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death. |
| PC-22971 |
CIB-1476
pro-caspase-1 inhibitor
|
CIB-1476 is an irreversible covalent inhibitor of pro-caspase-1 with IC50 of 0.65 uM, covalently targets pro-caspase-1 Cys285 and Cys397, inhibits NLRP3 inflammasome activation. |
| PC-22752 |
Ac-YVAD-cmk
Caspase-1 inhibitor
|
Ac-YVAD-cmk is a tetrapeptide, selective caspase-1 (interleukin-1 beta converting enzyme, ICE) inhibitor with neuroprotective and anti-inflammatory effects, inhibits pyroptosis (caspase-1-activated cell death). |
| PC-49742 |
NS3694
Caspase inhibitor
|
NS3694 (NS 3694) is a specific cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation, blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with IC50 of 50 uM. |
| PC-73051 |
Procaspase-6 inhibitor 13
Procaspase-6 inhibitor
|
Procaspase-6 inhibitor 13 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.38 uM. |
| PC-73050 |
Procaspase-6 inhibitor 12
Procaspase-6 inhibitor
|
Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM. |
| PC-73049 |
PG3d
Caspase-6 inhibitor
|
PG3d (Caspase-6 inhibitor PG3d) is a cell-active, allosteric and irreversible, non-competitive Caspase-6 inhibitor. |
| PC-72960 |
NH-23-C2
Caspase-2 inhibitor
|
NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8. |
| PC-35176 |
Ac-IEPD-CHO
Granzyme B inhibitor
|
Ac-IEPD-CHO (Ac-Ile-Glu-Pro-Asp-CHO) is a potent, reversible inhibitor of serine protease Granzyme B (GzmB) with Ki of 80 nM, also inhibits caspase-7 (Ki=550 nM) and induces apoptosis. |
| PC-63279 |
ML132
Caspase-1 inhibitor
|
ML132 (NCGC-00183434, CID-4462093) is a highly potent, selective Caspase 1 inhibitor with IC50 of 0.023 nM, displays >1,000-fold selectivity over a panel of 9 caspases.. |
