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首页-小分子抑制剂&激动剂-Apoptosis-Caspase-VRT-043198
VRT-043198

Chemical Structure : VRT-043198

CAS No.: 244133-31-1

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VRT-043198 (VRT043198)

货号: PC-28002Not For Human Use, Lab Use Only.

VRT-043198 is the active metabolite of Belnacasan (VX-765), which is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1, exhibits Ki of 0.8 nM and 0.6 nM for ICE/Caspase-1 and Caspase-4, respectively.

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10 mg ￥1480 In stock
25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VRT-043198 is the active metabolite of Belnacasan (VX-765), which is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/Caspase-1, exhibits Ki of 0.8 nM and 0.6 nM for ICE/Caspase-1 and Caspase-4, respectively.

物理化学性质&存储条件

分子量 480.95
分子式 C22H29ClN4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-((S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-4-oxobutanoic acid

参考文献

1. Woods Wannamaker, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16.

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