Tetrapeptide KGR-3 (Ac-WEHD-AOMK) | Caspase-1/Caspase-4 inhibitor

Chemical Structure : Tetrapeptide KGR-3

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Tetrapeptide KGR-3 (Ac-Trp-Glu-His-Asp-AOMK, Ac-WEHD-AOMK)

货号: PC-27890Not For Human Use, Lab Use Only.

Tetrapeptide KGR-3 (Ac-WEHD-AOMK) is potent and somewhat selective inhibitor of caspase-1 and caspase-4, inhibits caspase-1- or caspase-4-driven pyroptosis and IL-1β secretion.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Tetrapeptide KGR-3 (Ac-WEHD-AOMK) is potent and somewhat selective inhibitor of caspase-1 and caspase-4, inhibits caspase-1- or caspase-4-driven pyroptosis and IL-1β secretion.
KGR-3 also inhibits mouse caspase-1.
KGR-3 inhibits nigericin-induced cell lysis.
KGR-3 blocks GSDMD processing and cell death induced by caspase-4 but is less effective against caspase-11.
KGR-3 suppressed Val-boroPro (VBP)-induced pyroptosis in EA.hy926 cells with IC50 of 2.5 uM.
KGR-3 prevents caspase-1-dependent pyroptosis, but not caspase-1-dependent apoptosis.

物理化学性质&存储条件

分子量	773.80
分子式	C38H43N7O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4S,7S,10S,13S)-10-((1H-imidazol-5-yl)methyl)-4-((1H-indol-3-yl)methyl)-7-(2-carboxyethyl)-13-(2-((2,6-dimethylbenzoyl)oxy)acetyl)-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

参考文献

1. Groborz KM, et al. Nature. 2026 Aug 3. doi: 10.1038/s41586-026-10957-y.

Tetrapeptide KGR-3 (Ac-Trp-Glu-His-Asp-AOMK, Ac-WEHD-AOMK)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Tetrapeptide KGR-3 (Ac-Trp-Glu-His-Asp-AOMK, Ac-WEHD-AOMK)

生物&药学活性

物理化学性质&存储条件

参考文献

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