| Cat. No. |
Product Name |
Information |
| PC-25499 |
SIRT2 inhibitor KPM-2
SIRT2 inhibitor
|
KPM-2 is a potent, selective, substrate-competitive sirtuin-2 (SIRT2) inhibitor with IC50 of 55 nM, >25-fold selective over SIRT1 and SIRT3. |
| PC-25498 |
SIRT2 inhibitor AF8
SIRT2 inhibitor
|
SIRT2 inhibitor AF8 is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.06 uM. |
| PC-25497 |
SIRT2 inhibitor 24a
SIRT2 inhibitor
|
SIRT2 inhibitor 24a is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.85 uM. |
| PC-25496 |
SIRT2 inhibitor RW-78
SIRT2 inhibitor
|
SIRT2 inhibitor RW-78 is a potent, ubtype selective, NAD+ independent SIRT2 inhibitor with IC50 of 26 nM, has high selective against SIRT1, 3 and 5, shows cellular target engagement via NanoBRET assays in HEK293T cells with EC50 of 15 nM. |
| PC-25249 |
SIRT3 inhibitor 77-39
SIRT3 inhibitor
|
SIRT3 inhibitor 77-39 is a selective small molecule inhibitor of SIRT3 with KD of 2.14 uM, 14-fold against SIRT2 and little inhibition on SIRT1. |
| PC-25052 |
Forvisirvat
SIRT6 activator
|
Forvisirvat (SP‐624) is a selective, orally active sirtuin 6 (SIRT6) activator. |
| PC-24824 |
SKLB-11A
SIRT3 activator
|
SKLB-11A is a specific, allosteric small molecule SIRT3 activator, directly targets and activates SIRT3 with EC50 of 21.95 uM, effectively binds to SIRT3 with SPR Kd of 4.7 uM. |
| PC-24697 |
NPD11033
SIRT2 inhibitor
|
NPD11033 is a potent, selective, and cellular effective SIRT2 inhibitor with IC50 of 0.46 uM, inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. |
| PC-24533 |
DDL-218
SirT1 enhancer
|
DDL-218 is an orally brain-permeable small-molecule sirtuin 1 (SirT1) enhancer, increases SirT1 protein levels in ApoE4-expressing N2a (N2a-E4) murine neuroblastoma cells. |
| PC-24360 |
Rhynchophylline
SIRT3 agonist
|
Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum and EphA4 inhibitor, also is a selective Sirtuin 3 (SIRT3) agonist, prevents mitochondrial dysfunction by regulating the SIRT3/SOD2 pathway. |
| PC-23870 |
Nicotinamide riboside
NAD+ precursor
|
Nicotinamide riboside (NR) is an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3, promotes peroxisome proliferator-activated receptor-γ coactivator 1 (PGC)-1α expression in the brain. |
| PC-23756 |
Guttiferone G
SIRT1/SIRT2 inhibitor
|
Guttiferone G is small molecule inhibitor of recombinant human SIRT1 and SIRT with IC50 of 9 uM and 22 uM, respectively. |
