| Cat. No. |
Product Name |
Information |
| PC-42395 |
AK-1
SIRT2 inhibitor
|
AK-1 is a potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM. |
| PC-42309 |
Salermide
SIRT1/SIRT2 inhibitor
|
Salermide is a potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively. |
| PC-25501 |
Tenovin-6 hydrochloride
SIRT2 inhibitor
|
Tenovin-6 hydrochloride is a small-molecule p53 activator, inhibits purified human SirT1 deacetylase activity in vitro with IC50 of 21 μM and human SirT2 activity with IC50 of 10 μM. |
| PC-25500 |
Tenovin-6
SIRT2 inhibitor
|
Tenovin-6 is a small-molecule p53 activator, inhibits purified human SirT1 deacetylase activity in vitro with IC50 of 21 μM and human SirT2 activity with IC50 of 10 μM. |
| PC-25499 |
SIRT2 inhibitor KPM-2
SIRT2 inhibitor
|
KPM-2 is a potent, selective, substrate-competitive sirtuin-2 (SIRT2) inhibitor with IC50 of 55 nM, >25-fold selective over SIRT1 and SIRT3. |
| PC-25498 |
SIRT2 inhibitor AF8
SIRT2 inhibitor
|
SIRT2 inhibitor AF8 is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.06 uM. |
| PC-25497 |
SIRT2 inhibitor 24a
SIRT2 inhibitor
|
SIRT2 inhibitor 24a is a potent, subtype selective SIRT2 inhibitor with IC50 of 0.85 uM. |
| PC-25496 |
SIRT2 inhibitor RW-78
SIRT2 inhibitor
|
SIRT2 inhibitor RW-78 is a potent, ubtype selective, NAD+ independent SIRT2 inhibitor with IC50 of 26 nM, has high selective against SIRT1, 3 and 5, shows cellular target engagement via NanoBRET assays in HEK293T cells with EC50 of 15 nM. |
| PC-25249 |
SIRT3 inhibitor 77-39
SIRT3 inhibitor
|
SIRT3 inhibitor 77-39 is a selective small molecule inhibitor of SIRT3 with KD of 2.14 uM, 14-fold against SIRT2 and little inhibition on SIRT1. |
| PC-25052 |
Forvisirvat
SIRT6 activator
|
Forvisirvat (SP‐624) is a selective, orally active sirtuin 6 (SIRT6) activator. |
| PC-24824 |
SKLB-11A
SIRT3 activator
|
SKLB-11A is a specific, allosteric small molecule SIRT3 activator, directly targets and activates SIRT3 with EC50 of 21.95 uM, effectively binds to SIRT3 with SPR Kd of 4.7 uM. |
| PC-24697 |
NPD11033
SIRT2 inhibitor
|
NPD11033 is a potent, selective, and cellular effective SIRT2 inhibitor with IC50 of 0.46 uM, inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. |
