SIRT2 inhibitor KPM-2

Chemical Structure : SIRT2 inhibitor KPM-2

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货号: PC-25499Not For Human Use, Lab Use Only.

KPM-2 is a potent, selective, substrate-competitive sirtuin-2 (SIRT2) inhibitor with IC50 of 55 nM, >25-fold selective over SIRT1 and SIRT3.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KPM-2 is a potent, selective, substrate-competitive sirtuin-2 (SIRT2) inhibitor with IC50 of 55 nM, >25-fold selective over SIRT1 and SIRT3.
KPM-2 engages in a nucleophilic attack toward NAD+ at the active site of SIRT2.
KPM-2 exhibits antiproliferative activity in cancer cells and remarkable neurite outgrowth activity.

物理化学性质&存储条件

分子量	738.90
分子式	C40H46N6O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl ((S)-1-(((S)-1-amino-1-oxopropan-2-yl)amino)-1-oxo-6-(2-(2-((3-phenethoxyphenyl)amino)benzamido)ethanethioamido)hexan-2-yl)carbamate

参考文献

1. Mellini P, et al. Chem Sci. 2017 Sep 1;8(9):6400-6408.