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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -Trilobatin
Trilobatin

Chemical Structure : Trilobatin

CAS No.: 4192-90-9

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Trilobatin

货号: PC-27436Not For Human Use, Lab Use Only.

Trilobatin is a natural dihydrochalcone extracted from Lithocarpus polystachyus, ameliorates pulmonary fibrosis by directly and specifically targeting MEK1-dependent ERK signaling, also is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope, also is a SIRT7 activator.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Trilobatin is a natural dihydrochalcone extracted from Lithocarpus polystachyus, ameliorates pulmonary fibrosis by directly and specifically targeting MEK1-dependent ERK signaling, also is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope, also is a SIRT7 activator.
Trilobatin effectively mitigates bleomycin (BLM)-induced pulmonary fibrosis in vivo and suppresses transforming growth factor-beta 1 (TGF-β1)-driven epithelial-mesenchymal transition (EMT) in vitro.
Trilobatin significantly attenuated pro-inflammatory cytokine secretion, limited inflammatory cell infiltration, preserved alveolar architecture, and decreased collagen deposition, ultimately leading to improved survival rates in fibrotic mice.
Trilobatin directly uncoupled the TGF-β-induced ERK signaling cascade by selectively inhibiting the phosphorylation of MEK1 and ERK1/2, without affecting the upstream activation of Raf1.
Trilobatin significantly increased the protein expressions of SIRT6, SIRT7, and VEGFA, but not affected SIRT1-SIRT5 protein expressions in mouse brain microvascular endothelium bEnd.3 cells.
Trilobatin directly binds to SIRT7, but also increases SIRT7 expression.
Trilobatin promotes cerebral microvascular endothelial cells proliferation, and facilitates angiogenesis after CIRI via mediating SIRT7/VEGFA signaling pathway in rats.
Trilobatin also inhibits PIKfyve activity in a dose-dependent manner with IC50 of 0.29 uM.

物理化学性质&存储条件

分子量 436.41
分子式 C21H24O10
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2,6-Dihydroxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(4-hydroxyphenyl)propan-1-one

参考文献

1. Zhao Y, et al. Eur J Pharmacol. 2026 Jul 21;1030:179161.

2. Shen K, et al. Redox Biol. 2026 Sep;95:104315.

3. Huang F, et al. Phytother Res. 2022 Jul;36(7):2940-2951.

4. Yin S, et al. FEBS Lett. 2018 Jul;592(13):2361-2377.

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