Tenovin-6

Chemical Structure : Tenovin-6

CAS No.: 1011557-82-6

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货号: PC-25500Not For Human Use, Lab Use Only.

Tenovin-6 is a small-molecule p53 activator, inhibits purified human SirT1 deacetylase activity in vitro with IC50 of 21 μM and human SirT2 activity with IC50 of 10 μM.

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5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

Tenovin-6 is a small-molecule p53 activator, inhibits purified human SirT1 deacetylase activity in vitro with IC50 of 21 μM and human SirT2 activity with IC50 of 10 μM.
Tenovin-6 weakly inhibits SirT3 activity with IC50 of 67 uM and does not inhibit HDAC8.
Tenovin-6 is active on mammalian cells at one-digit micromolar concentrations and decreases tumor growth in vivo as single agents.

物理化学性质&存储条件

分子量	454.63
分子式	C25H34N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(tert-Butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide

参考文献

1. Lain S, et al. Cancer Cell. 2008 May;13(5):454-63.

Tenovin-6

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Tenovin-6

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