| Cat. No. |
Product Name |
Information |
| PC-70212 |
Rilapladib
Lp-PLA2 inhibitor
|
Rilapladib (SB-659032, SB659032) is a potent, selective and oral lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.23 nM, for the treatment of Alzheimer's disease and atherosclerosis.. |
| PC-42240 |
ML348
APT-1 inhibitor
|
ML348 is a potent, selective Acyl protein thioesterase 1 (APT-1, LYPLA1) with IC50 of 210 nM, displays >10-fold selectivity over APT-2, >47-fold selectivity over a panel of >20 serine hydrolases. |
| PC-45957 |
SPK-601
PC-PLC inhibitor
|
SPK-601 (LMV-601) is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor. |
| PC-42634 |
Darapladib
Lp-PLA2 inhibitor
|
Darapladib (SB-480848) is a potent Lp-PLA2 inhibitor with IC50 of 0.25 nM, shows an enhanced in vitro and in vivo profile versus SB-435495. |
| PC-42702 |
CAY10650
cPLA2α inhibitor
|
CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 of 12 nM. |
| PC-45953 |
D609
PC-PLC inhibitor, SMS inhibitor
|
D609 is a competitive inhibitor of PC-PLC with Ki of 6.4 uM, also is a small molecule of sphingomyelin synthase (SMS1 and SMS2). |
| PC-26700 |
Bromoenol Lactone
iPLA2 inhibitor
|
Bromoenol Lactone (HELSS) is a potent, irreversible, selective inhibitor of calcium-independent phospholipase A2 (iPLA2, GVIA iPLA 2, iPLA2β) inhibitor with IC50 of 1 uM. |
| PC-26699 |
LY311727
PLA2 inhibitor
|
LY311727 (LY-311727) is a potent and selective inhibitor of human non-pancreatic secretory phospholipase A2 (group IIA sPLA2, PLA2-IIA, hnps-PLA2) with IC50 of 0.19 nM, 1,500-fold selectivity against porcine pancreatic s-PLA2. |
| PC-25982 |
AACOCF3
cPLA2 inhibitor
|
Arachidonyl trifluoromethyl ketone (AACOCF3) is an arachidonic acid analog and potent and selective, slow- and tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2), inhibits the release of AA from calcium ionophore-challenged U937 cells (IC50= 8 uM) and from platelets (IC50=2 uM). |
| PC-25738 |
ONO-RS-082
PLA2 inhibitor
|
ONO-RS-082 is a specific phospholipase A2 (PLA2) inhibitor with IC50 of 1.0 uM, does not inhibit PKC. |
