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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-AACOCF3
AACOCF3

Chemical Structure : AACOCF3

CAS No.: 149301-79-1

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AACOCF3 (Arachidonyl trifluoromethyl ketone)

货号: PC-25982Not For Human Use, Lab Use Only.

Arachidonyl trifluoromethyl ketone (AACOCF3) is an arachidonic acid analog and potent and selective, slow- and tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2), inhibits the release of AA from calcium ionophore-challenged U937 cells (IC50= 8 uM) and from platelets (IC50=2 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Arachidonyl trifluoromethyl ketone (AACOCF3) is an arachidonic acid analog and potent and selective, slow- and tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2), inhibits the release of AA from calcium ionophore-challenged U937 cells (IC50= 8 uM) and from platelets (IC50=2 uM).

物理化学性质&存储条件

分子量 356.47
分子式 C21H31F3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one

参考文献

1. Street IP, et al. Biochemistry. 1993 Jun 15;32(23):5935-40.

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