| Cat. No. |
Product Name |
Information |
| PC-28063 |
Tanshinone I
sPLA2/cPLA2 inhibitor, Syk inhibitor
|
Tanshinone I is a natural compound isolated from the roots of Salvia miltiorrhiza Bunge with antagonist activity at GABAA receptors, inhibits type IIA human recombinant sPLA2 (IC50=11 uM) and rabbit recombinant cPLA2 (IC50=82 uM), also is a Syk inhibitor (IC50=1.64 uM) and exhibits anti-mast cell degranulation activity in vitro (IC50=2.76 uM). |
| PC-26792 |
BAY-439
hPLA2-G5 inhibitor
|
BAY-439 is a potent and selective inhibitor of human phospholipase A2 Group V (hPLA2-G5) with biochemical IC50 of 7 nM and KD of 214 nM in the SPR binding assay. |
| PC-26344 |
ROC-0929
sPLA2-X inhibitor
|
ROC-0929 is a specific small molecule inhibitor of secreted phospholipase A2 group X (sPLA2-X, sPLA2s) with IC50 of 80 nM (hGX sPLA2), does not inhibit other mammalian sPLA2s. |
| PC-26186 |
Melittin
PLA2 activator
|
Melittin is a peptide phospholipase A2 (PLA2) activator, stimulates the activity of the low molecular weight PLA2, does not the increase activity of the high molecular weight PLA2. |
| PC-26014 |
BRI-50460
cPLA2 inhibitor
|
BRI-50460 is a potent, selective and brain-penetrant cytosolic calcium-dependent phospholipase A2 (cPLA2) inhibitor with IC50 of 0.88 nM for cellular arachidonic acid (AA) release and 4.1 nM for downstream PGE2 production. |
| PC-25365 |
ABD646
ABHD18 inhibitor
|
ABD646 is a selective, covalent, small-molecule inhibitor of ABHD18, rescues TAFAZZIN (TAZ) mutant phenotypes in fibroblasts from human patients and in fish embryos. |
| PC-24356 |
ABD778
ABHD17 inhibitor
|
ABD778 is a potent and selective, in vivo-active ABHD17 inhibitor with IC50 of 76 nM and 84 nM for both human and mouse ABHD17 enzymes, respectively, is the isopropyl ester analog of ABD957. |
| PC-23791 |
AVX420
cPLA2α inhibitor
|
AVX420 (GK420) is a potent and selective inhibitor of Group IVA cytosolic phospholipase A2 (cPLA2α), inhibits arachidonic acid (AA) release in IL-1β-stimulated SW982 synoviocyte with IC50 of 0.09 uM. |
| PC-23014 |
SLC13A3 inhibitor ACA
SLC13A3 inhibitor, PLA2 inhibitor
|
SLC13A3 inhibitor ACA ((E/Z)-BML264) is a small molecule inhibitor of SLC13A3, also is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker. |
| PC-22786 |
Giripladib
cPLA2 inhibitor
|
Giripladib (PLA-695) is a potent, specific cytoplasmic phospholipase A2 (cPLA2). |
| PC-22189 |
AX048
cPLA2 inhibitor
|
AX048 is a potent cytosolic group IVA phospholipase A2 (cPLA2) with analgesic effect. |
| PC-20922 |
VU533
NAPE-PLD activator
|
VU533 is a small molecule activator of N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) with EC50 of 0.3 uM, enhances efferocytosis by macrophages. |
