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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-Tanshinone I
Tanshinone I

Chemical Structure : Tanshinone I

CAS No.: 568-73-0

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Tanshinone I

货号: PC-28063Not For Human Use, Lab Use Only.

Tanshinone I is a natural compound isolated from the roots of Salvia miltiorrhiza Bunge with antagonist activity at GABAA receptors, inhibits type IIA human recombinant sPLA2 (IC50=11 uM) and rabbit recombinant cPLA2 (IC50=82 uM), also is a Syk inhibitor (IC50=1.64 uM) and exhibits anti-mast cell degranulation activity in vitro (IC50=2.76 uM).

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25 mg ￥580 In stock
50 mg ￥880 In stock
100 mg ￥1380 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tanshinone I is a natural compound isolated from the roots of Salvia miltiorrhiza Bunge with antagonist activity at GABAA receptors, inhibits type IIA human recombinant sPLA2 (IC50=11 uM) and rabbit recombinant cPLA2 (IC50=82 uM), also is a Syk inhibitor (IC50=1.64 uM) and exhibits anti-mast cell degranulation activity in vitro (IC50=2.76 uM).
Tanshinone I ameliorates the learning and memory impairments induced by diazepam and MK-801 through activation of ERK signalling.
Tanshinone I also inhibits SARS-CoV-2 PLpro with IC50 of 2.21 uM.
Tanshinone I inhibits PGE(2) formation from LPS-induced RAW macrophages with IC50 of 38 uM.
Tanshinone I shows in vivo antiinflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis.

物理化学性质&存储条件

分子量 276.29
分子式 C18H12O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione

参考文献

1. Kim DH, et al. Br J Pharmacol. 2009 Oct;158(4):1131-42.

2. Zhao Y, et al. Protein Cell. 2021 Nov;12(11):877-888.

3. Wang X, et al. Molecules. 2018 Nov 28;23(12):3114.

4. Kim SY, et al. Phytother Res. 2002 Nov;16(7):616-20.

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