| Cat. No. |
Product Name |
Information |
| PC-43497 |
Sapanisertib
mTORC1/2 inhibitor
|
Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms. |
| PC-43313 |
Torin2
mTOR inhibitor
|
Torin2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25 nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases. |
| PC-43314 |
Torin1
mTOR inhibitor
|
Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM). |
| PC-43029 |
Zotarolimus
FKBP ligand
|
Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin. |
| PC-42848 |
WYE-354
mTOR inhibitor
|
WYE-354 is a potent, selective and ATP-competitive inhibitor of mTOR with IC50 of 5 nM (recombinant mTOR ), displays >100-fold selectivity over PI3K isofoms. |
| PC-62364 |
CID3528206
Yeast TORC1 inhibitor
|
CID3528206 is a potent, small molecule yeast TORC1 inhibitor that inhibits TORC1 activity both in vitro and in vivo with IC50 of 150 nM and 3.9 uM, respectively. |
| PC-60920 |
mTOR inhibitor 10
mTOR inhibitor
|
mTOR inhibitor 10 is a potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM. |
| PC-60555 |
NV-128
mTOR inhibitor
|
NV-128 (LY-303511) is a novel isoflavone derivative that inhibits mTOR and promotes caspase-independent cell death. |
| PC-60554 |
ME-344
mTOR inhibitor, HO-1 inhibitor
|
ME-344 (NV-344) is a novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM, also targets heme oxygenase 1 (HO-1) and disrupts redox homeostasis. |
| PC-60482 |
AZD3147
mTOR inhibitor
|
AZD3147 is a potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM. |
| PC-60418 |
RapaLink-1
mTOR inhibitor
|
RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors. |
| PC-60132 |
Temsirolimus
mTOR inhibitor
|
Temsirolimus (CCI779, Torisel) is a rapamycin ester and mTOR inhibitor with biochemical IC50 of 1.74 uM. |
