GPI-1046 |CAS:186452-09-5 Probechem Biochemicals

Chemical Structure : GPI-1046

CAS No.: 186452-09-5

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GPI-1046 (GPI1046;GPI 1046)

货号: PC-63577Not For Human Use, Lab Use Only.

GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
GPI-1046 induces ARNT expression with subsequent activation of ALK3-dependent canonical BMP signaling responses and attenuates chronic organ failure in models of chronic kidney, but also cardiac and liver injuries; reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats.

物理化学性质&存储条件

分子量	360.454
分子式	C20H28N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate

参考文献

1. Sauer H, et al. Brain Res. 1999 Sep 18;842(1):109-18.

2. Burnett AL, et al. Urology. 2005 May;65(5):1003-7.

3. Sari Y, et al. Neuroscience. 2012 Dec 27;227:327-35.

4. Tampe B, et al. J Clin Invest. 2018 Apr 17. pii: 89632.

GPI-1046 (GPI1046;GPI 1046)

生物&药学活性

物理化学性质&存储条件

参考文献

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GPI-1046 (GPI1046;GPI 1046)

生物&药学活性

物理化学性质&存储条件

参考文献

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