| Cat. No. |
Product Name |
Information |
| PC-28062 |
Tanshinone IIA
VEGFR2 inhibitor, HDAC6 inhibitor
|
Tanshinone IIA is a major component of the root of red-rooted Salvia miltiorrhiza Bunge with potent antitumor activity, suppresses A549 proliferation, induces apoptosis and cell cycle arrest at the S phase by targeting the protein kinase domains of VEGF/VEGFR2, also directly inhibits HDAC6 enzymatic activity and selectively kills U266 and RPMI 8226 myeloma cells. |
| PC-27919 |
NAT-6-321056
VEGFR2 inhibitor
|
NAT-6-321056 is a novel modulator of VEGFR2 signaling, exhibits potent anti-angiogenic and anti-tumor activities, inhibits VEGFR2 kinase activity with IC50 of 11.7 uM and KD of 3.829 uM. |
| PC-27813 |
ATWLPPR peptide
NRP-1 inhibitor
|
ATWLPPR peptide (A7R, Ala-Thr-Trp-Leu-Pro-Pro-Arg) is a specific heptapeptide NRP-1 (Neuropilin 1, NRP1) inhibitor and effective antagonist of the VEGF165 binding to NRP-1 with IC50 of 5.9 uM blocks vascular endothelial growth factor (VEGF)-mediated angiogenesis. |
| PC-23664 |
EG01377 dihydrochloride
NRP1 inhibitor
|
EG01377 dihydrochloride is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2. |
| PC-22874 |
TU2218
ALK5/VEGFR2 inhibitor
|
Tosposertib (TU2218) is a small-molecule inhibitor that inhibits dual ALK5/VEGFR2 with IC50 of 1.2 nM and 4.5 nM respectively. |
| PC-21503 |
SYHA1813
CSF1R/VEGFR inhibitor
|
SYHA1813 is a potent dual inhibitor of CSF1R and VEGFR with IC50 of 19.3, 2.8, 0.3, and 4.3 nM for CSF1R, VEGFR1, 2, and 3, respectively. |
| PC-21447 |
NRPa-308
NRP1 inhibitor
|
NRPa-308 is a neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity. |
| PC-20795 |
Chiauranib
Multikinase inhibitor
|
Chiauranib (Ibcasertib, CS2164) is a potent multi-kinase inhibitor, inhibits VEGFR2, Aurora B and CSF-1R kinases with IC50 values of 7, 9 and 7 nM, respectively. |
| PC-20338 |
EVT801
VEGFR-3 inhibitor
|
EVT801 (EVT 801) is a potent, selective VEGFR-3 inhibitor with biochemical IC50 of 11 nM, inhibits cellular VEGFR-3 autophosphorylation with IC50 of 39 nM. |
| PC-38754 |
VEGFR inhibitor F16
Angiogenesis inhibitor
|
F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation. |
| PC-38423 |
Timtraxanib
VEGFR-2 inhibitor
|
Timtraxanib (AVI 3207) is a peptide mimetic acting as a selective VEGFR-2 inhibitor, inhibits VEGF-2 selectively for curing senile macular degeneration. |
| PC-73181 |
SAR131675
VEGFR3 inhibitor
|
SAR131675 is a potent and selective VEGFR3 inhibitor with IC50 of 23 nM. |
