NAT-6-321056

Chemical Structure : NAT-6-321056

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货号: PC-27919Not For Human Use, Lab Use Only.

NAT-6-321056 is a novel modulator of VEGFR2 signaling, exhibits potent anti-angiogenic and anti-tumor activities, inhibits VEGFR2 kinase activity with IC50 of 11.7 uM and KD of 3.829 uM.

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生物&药学活性

NAT-6-321056 is a novel modulator of VEGFR2 signaling, exhibits potent anti-angiogenic and anti-tumor activities, inhibits VEGFR2 kinase activity with IC50 of 11.7 uM and KD of 3.829 uM.
NAT-6-321056 inhibits VEGF-induced cell viability, tube formation, and VEGFR2 phosphorylation in EA.hy 926 cells.
NAT-6-321056 suppresses VEGFR2-associated signaling pathways in EA.hy 926 and SK-N-DZ cells.
NAT-6-321056 (10-20 uM) inhibits angiogenesis in a chorioallantoic membrane model.
NAT-6-321056 shows anti-tumor and anti-angiogenic effects in SK-N-DZ cell-derived zebrafish xenografts.

物理化学性质&存储条件

分子量	496.61
分子式	C30H32N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-((6-([1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydropyrimidin-2-yl)amino)hexahydrofuro[3,2-b]furan-3-yl)-4-methylbenzamide

参考文献

1. Lei X, et al. Biochem Pharmacol. 2026 Aug 12;253(Pt 2):118353.

NAT-6-321056

生物&药学活性

物理化学性质&存储条件

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NAT-6-321056

生物&药学活性

物理化学性质&存储条件

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