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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-Tanshinone IIA
Tanshinone IIA

Chemical Structure : Tanshinone IIA

CAS No.: 568-72-9

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Tanshinone IIA

货号: PC-28062Not For Human Use, Lab Use Only.

Tanshinone IIA is a major component of the root of red-rooted Salvia miltiorrhiza Bunge with potent antitumor activity, suppresses A549 proliferation, induces apoptosis and cell cycle arrest at the S phase by targeting the protein kinase domains of VEGF/VEGFR2, also directly inhibits HDAC6 enzymatic activity and selectively kills U266 and RPMI 8226 myeloma cells.

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50 mg ￥1180 In stock
100 mg ￥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tanshinone IIA is a major component of the root of red-rooted Salvia miltiorrhiza Bunge with potent antitumor activity, suppresses A549 proliferation, induces apoptosis and cell cycle arrest at the S phase by targeting the protein kinase domains of VEGF/VEGFR2, also directly inhibits HDAC6 enzymatic activity and selectively kills U266 and RPMI 8226 myeloma cells.
Tanshinone IIA attenuates myocardial ischemia by targeting FGFR1 residue Gln284 for allosteric modulation and subsequent autophagy inhibition.
Tanshinone IIA inhibits choroidal neovascularization and restores outer blood-retinal barrier function in Vldlr knockout mice.
Tanshinone IIA induced apoptosis in HL60 human premyelocytic leukemia cell line.
Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1.

物理化学性质&存储条件

分子量 294.35
分子式 C19H18O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione

参考文献

1. Yoon Y, et al. J Ethnopharmacol. 1999 Dec 15;68(1-3):121-7.

2. Shan H, et al. Br J Pharmacol. 2009 Nov;158(5):1227-35.

3. Wei P, et al. Exp Eye Res. 2026 Oct;271:111158.

4. Xie J, et al. Acta Pharm Sin B. 2015 Nov;5(6):554-63.

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